Computational Systems Pharmacology and Toxicology PDF
By:Rudy J Richardson,Dale E Johnson
Published on 2017-03-03 by Royal Society of Chemistry
The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.
This Book was ranked at 5 by Google Books for keyword Toxicology.
Book ID of Computational Systems Pharmacology and Toxicology's Books is EC5EDgAAQBAJ, Book which was written byRudy J Richardson,Dale E Johnsonhave ETAG "6UG5SQ21/zc"
Book which was published by Royal Society of Chemistry since 2017-03-03 have ISBNs, ISBN 13 Code is 9781782623328 and ISBN 10 Code is 1782623329
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Book which have "347 Pages" is Printed at BOOK under CategoryMedical
Book was written in en
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